伊恩·D. 孟,Ph值.D.
Professor, Department of Biomedical 科学s
Director, Center of Biomedical 研究 Excellence for the Study of 疼痛 and Sensory Function
Director, Center for Excellence in the 神经科学s
位置
Dr. Ian 孟 received his ScB and PhD in 神经科学 at 布朗大学. Following completion of his PhD, he worked as a postdoctoral fellow with Dr. Howard Fields in the Department of Neurology at the University of California, 旧金山(UCSF), studying the brain circuits mediating the analgesic properties of cannabinoids. Dr. 孟 joined the University of New England (UNE) in 2003 where he is currently a professor of Biomedical 科学s, Director of the Center for Excellence in the 神经科学s (CEN), and the Director of the National Institute of 健康 (NIH) funded Center for the Study of 疼痛 and Sensory Function. 在全球网络赌博平台, he has maintained a continuously funded research program with the aim of understanding trigeminal sensory processing underlying headache and ocular 疼痛 and homeostasis, with an emphasis on two conditions: headache and dry eye. Dr. 孟's lab is currently investigating sensory neurons that regulate tearing and ocular 疼痛 under both normal and pathological conditions such as dry eye. Additional projects are exploring the ability of corneal afferents to promote corneal healing by providing trophic support to the injured cornea in dry eye.
凭证
教育
博士后训练
University of California, San Francisco (San Francisco, California)
研究
目前的研究
博士的总体目标. 孟's research is to understand trigeminal sensory processing underlying headache and ocular 疼痛 and homeostasis, with an emphasis on two conditions: medication overuse headache and dry eye syndrome. Dr. 孟's lab is currently investigating sensory neurons that regulate tearing and ocular 疼痛 under both normal and pathological conditions such as dry eye. 在与头痛相关的研究中. 孟's research aims to understand the neuroplastic changes induced by the chronic use of analgesics, as such treatments have been shown to transform episodic migraines into chronic daily headache.
选定的出版物
1. Hitomi S, Kross K, Kurose M, Porreca F, 孟 ID. Activation of dura-sensitive trigeminal neurons and increased c-Fos protein induced by morphine withdrawal in the rostral ventromedial medulla. 头痛. 2016年5月6日. pii: 0333102416648655.[Epub ahead of print] PubMed PMID: 27155000.
2. Harasawa I, Johansen JP, Fields HL, Porreca F, 孟 ID. Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons. 疼痛. 2016年1月,157 (1):166 - 73. doi: 10.1097/j.疼痛.0000000000000344. PubMed PMID: 26335909; PubMed Central PMCID: PMC4829402.
3. 孟 ID, Barton ST, Mecum NE, Kurose M. Corneal sensitivity following lacrimal gland excision in the rat. 投资眼科视觉科学. 2015年5月,56 (5):3347 - 54. doi: 10.1167 / iovs.15-16717. PubMed PMID: 26024120; PubMed Central PMCID: PMC4453983.
4. 孟 ID, Kurose M. The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. 眼部护理经验. 2013年12月,117:79 - 87. doi: 10.1016/j.前女友.2013.08.011. 审查. PubMed PMID: 23994439; PubMed Central PMCID: PMC3989072.
5. Kurose M, 孟 ID. Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells. J Neurophysiol. 2013年7月,110 (2):495 - 504. doi: 10.1152/jn.00222.2013. PubMed PMID: 23636717; PubMed Central PMCID: PMC3727064.
6. Robbins A, Schmitt D, Winterson BJ, 孟 ID. 慢性吗啡增加
Fos-positive neurons after concurrent cornea and tail stimulation. 头疼。. 2012年2月,52 (2):262 - 73. doi: 10.1111/j.1526-4610.2011.01999.x. PubMed PMID: 21929659;PubMed Central PMCID: PMC3244550.
7. 张建军，张建军，张建军. Selective ablation of mu-opioid receptor expressing neurons in the rostral ventromedial medulla attenuates stress-induced mechanical hypersensitivity. 生命科学. 2011年8月29日;89(9-10):313-9. doi: 10.1016/j.lfs.2011.06.024. PubMed PMID: 21763327.
8. 孟 ID, Dodick D, Ossipov MH, Porreca F. Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies. 头痛. 2011年5月,31 (7):851 - 60. doi: 10.1177/0333102411402367. 审查. PubMed PMID: 21444643.
9. Kurose M, 孟 ID. Corneal dry-responsive neurons in the spinal trigeminal nucleus respond to innocuous cooling in the rat. J Neurophysiol. 2013年5月,109(10):2517 - 22所示. doi: 10.1152/jn.00889.2012. PubMed PMID: 23446686; PubMed Central PMCID: PMC3653041.
10. Robbins A, Kurose M, Winterson BJ, 孟 ID. Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents. 投资眼科视觉科学. 2012年10月9日;53(11):7034-42. doi: 10.1167 / iovs.12-10025. PubMed PMID: 22952122; PubMed Central PMCID: PMC3471555.
研究兴趣
Ocular 疼痛; dry eye; migraine headache; medication overuse headache; transformation of migraine headache to chronic daily headache.